This white paper summarizes what is known about musculoskeletal disorders (MSDs) in the United States and their relationship to employment. We review the major existing clinical, epidemiological and labour market evidence on the prevalence and impact of MSDs in the U.S. working-age population. Musculoskeletal disorders represent a group of conditions that affect the muscles, tendons, ligaments, joints, peripheral nerves and supporting blood vessels in the body. MSDs constitute a significant proportion of the disease burden in the United States and have substantial economic implications. Of particular interest to this paper is the impact that MSDs have on people of working age. The white paper draws on a literature review of the existing academic and grey literature looking at the prevalence and impact of MSDs on the labour market in the United States.