Here you'll find new evidence and guidance from various sources across a variety of conditions of relevance to different audiences.

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Population Health to Personalized Medicine: Connecting Disease Indicators to Work Outcomes - Diabetes

The CWHP report "Population Health to Personlized Medicine: Connecting Disease Indicators to Work Outcomes - Type 2 Diabetes" presents a framework for connecting disease indicators of diabetes to a variety of work outcomes including absence, job performance, work disability and permanent departure from the workforce. The framework outlines connections between clinical and employer perspectives around worker health and suggests a variety of ways to improve diagnosis and treatment for better health and work-related outcomes.

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How Employers Use Evidence to Make Employee Health Investment Decisions

The CWHP report "The Employer's Role in Using Research-Based Healthcare Evidence" presents findings and recommendations from a series of interviews with employers and their programmatic solutions partners.  

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Tackling Chronic Pain While Reducing Opioid Use

A health system in Washington instituted a clinical plan that has succeeded in lowering patients’ opioid doses, according to a PCORI-funded study.

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Linking Community-Based Organizations with Each Other, and with Hospitals and Health Clinics, to Help Connect Patients with the Services They Need

The residents of urban centers suffer from many health and social problems. In East Baltimore (EB), many barriers frustrate residents’ aspirations to achieve health and well-being. Community-based organizations (CBO) can help but reach only a fraction of potential clients. Hospitals, providers, and community members often are unaware of available medical and community-based services. Community engagement can improve understanding and use of healthcare services, thereby improving patient outcomes.

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Can Coping-Skills Training Help Patients Who Have Received Intensive Hospital Care to Cope with Depression and Anxiety?

Why is this important? Nearly 800,000 Americans receive mechanical ventilation for acute respiratory failure in the intensive care unit (ICU) each year. Afterward, more than 60% of both patients and their family caregivers suffer from psychological distress, such as depression, anxiety, and post-traumatic stress disorder (PTSD) for longer than a year after discharge. Patients and families told us that they need help with their distress because it worsens their quality of life.

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Is a Patient Navigation Program More Helpful than a Referral Program for Reducing Depression and Improving Quality of Life among Women Living in Neighborhoods with Few Resources?

Background: Socioeconomically disadvantaged (SD) women are at elevated risk for depression and poor treatment engagement and outcomes. Many use obstetric/gynecology (OB/GYN) practices as their primary resource for physical and mental health care. Yet their depression most often goes unrecognized and unaddressed within OB/GYN, and, when addressed, engagement and outcomes are poor. Patients at the greatest risk include those with multiple biomedical and psychosocial problems, trauma exposure, healthcare barriers, and experiencing a lack of empowerment over one’s own health.

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Pilot Project: Predicting Who Will Respond Best to Medical Treatments

Recent evidence shows that the results of randomized clinical trials might not apply to individual patients in a straightforward way, even to those within the trial. While randomization ensures the comparability of treatment groups overall, there remain important differences between individuals in each treatment group that can dramatically affect the likelihood of benefiting from or being harmed by a therapy. Averaging effects across such different patients can give misleading results to physicians who care for individual, not average, patients.

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Helping Adults with Serious Mental Illness Improve Their Health and Wellness

This research project is in progress. PCORI will post the research findings on this page within 90 days after the results are final. What is the research about? Serious mental illness such as depression, bipolar disorder, or schizophrenia can make it hard for a person to get the health care they need, and their health problems may not be diagnosed or may get worse.

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Does Daily Self-Monitoring of Blood Sugar Levels Improve Blood Sugar Control and Quality of Life for Patients with Type 2 Diabetes Who Do Not Use Insulin?

For the nearly 75% of patients living with type 2 diabetes (T2DM) who do not use insulin, decisions regarding self-monitoring of blood glucose (SMBG) is unclear. SMBG testing is a resource-intensive activity without firmly established patient benefits. While SMBG holds great promise for sparking favorable behavioral change, the potential for no benefit or even patient harm must be acknowledged. Possible negative effects on patient quality of life must be more closely examined along with the speculative benefits of SMBG in non-insulin–treated T2DM.

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Treating Chronic Pain Using Approaches Adapted for Patients with Limited Reading Skills

Chronic pain is a significant public health problem that affects more than 116 million Americans; costs $600 billion annually; and is unequally borne by people in low-income brackets, especially ethnic minorities. Many individuals also have health literacy deficits (difficulty understanding their illness and difficulty navigating the healthcare system for treatment), putting them at a greater disadvantage in the healthcare system. Treatment usually relies on expensive medical interventions with negative side effects.